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Wednesday, September 30, 2020

Twins get 'mystifying' DNA ancestry test results

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According to 23andMe's findings, Charlsie has nearly 10 per cent less "broadly European" ancestry than Carly. She also has French and German ancestry (2.6 per cent) that her sister doesn't share.

The identical twins also apparently have different degrees of Eastern European heritage — 28 per cent for Charlsie compared to 24.7 per cent for Carly. And while Carly's Eastern European ancestry was linked to Poland, the country was listed as "not detected" in Charlsie's results.

"The fact that they present different results for you and your sister, I find very mystifying," said Dr. Mark Gerstein, a computational biologist at Yale University.

Twins' DNA 'shockingly similar'
Marketplace sent the results from all five companies to Gerstein's team for analysis.

He says any results the Agro twins received from the same DNA testing company should have been identical.

And there's a simple reason for that: The raw data collected from both sisters' DNA is nearly exactly the same.

"It's shockingly similar," he said.

The team at Yale was able to download and analyze the raw data set that each company used to perform its calculations.

An entire DNA sample is made up of about three billion parts, but companies that provide ancestry tests look at about 700,000 of those to spot genetic differences.

According to the raw data from 23andMe, 99.6 per cent of those parts were the same, which is why Gerstein and his team were so confused by the results. They concluded the raw data used by the other four companies was also statistically identical.

Still, none of the five companies provided the same ancestry breakdown for the twins.

"We think the numbers should be spot on the same," Gerstein said.

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